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Loop Diuretic Dose Equivalence Calculator (Furosemide, Torsemide, Bumex)

Convert clinical loop diuretic doses between Oral and IV Furosemide (Lasix), Torsemide (Demadex), and Bumetanide (Bumex) based on pharmacokinetics.

Calculated Results

Equivalent Loop Diuretic Regimens
Furosemide 40mg PO = Torsemide 20mg PO
Classic Clinical Ratio: Furosemide Oral 40mg ≈ Furosemide IV 20mg ≈ Torsemide 20mg ≈ Bumetanide 1mg
Oral Furosemide (Lasix)
40 mg Oral
Intravenous Furosemide (IV)
20 mg IV (1:2 ratio)
Oral Torsemide (Demadex)
20 mg Oral (Long half-life)
Bumetanide (Bumex)
1.0 mg PO / IV
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Frequently Asked Questions

What is the standard clinical loop diuretic equivalence ratio?

The classic pharmacology conversion ratio is: Oral Furosemide 40 mg = IV Furosemide 20 mg = Oral Torsemide 20 mg = Bumetanide 1 mg (40:20:20:1 ratio).

Why does IV Furosemide require half the oral dose (1:2 conversion)?

Oral furosemide has erratic and incomplete gastrointestinal bioavailability averaging 50% (ranging from 10% to 90% in decompensated heart failure due to gut edema). Therefore, switching from oral to IV requires cutting the dose by half.

What are the clinical advantages of Torsemide over Furosemide?

Torsemide boasts consistent high oral bioavailability (80%–100%) unhindered by food, a significantly longer elimination half-life (3–4 hours vs 1.5–2 hours), and anti-aldosterone properties that reduce cardiac remodeling.

What is the 'ceiling dose' in loop diuretic resistance?

In severe renal impairment (eGFR < 30), standard doses fail to reach the loop of Henle. The single-dose ceiling threshold is typically 80 to 160 mg of IV furosemide; exceeding the ceiling dose provides zero additional diuresis while increasing ototoxicity risk.