HOMA-IR Insulin Resistance & Sensitivity Calculator
Calculate HOMA-IR insulin resistance score, QUICKI insulin sensitivity index, and beta-cell pancreatic function from fasting blood glucose and insulin levels.
Calculated Results
Frequently Asked Questions
What is the HOMA-IR score and why is it superior to fasting glucose alone?
The Homeostatic Model Assessment of Insulin Resistance (HOMA-IR) evaluates how hard your pancreas works to maintain blood glucose. Many people have 'normal' fasting glucose (e.g. 90 mg/dL) for 10 to 15 years before type 2 diabetes diagnosis because their pancreas produces compensating surges of insulin (e.g., 20 μIU/mL).
What is the clinical formula for HOMA-IR?
Formula: HOMA-IR = [Fasting Glucose (mg/dL) × Fasting Insulin (μIU/mL)] / 405. (If glucose is in mmol/L, divide by 22.5).
What are the clinical HOMA-IR cutoffs?
HOMA-IR < 1.0: Optimal insulin sensitivity; 1.0 to 1.9: Normal/early warning; 1.9 to 2.9: Significant insulin resistance; > 3.0: Severe insulin resistance and metabolic dysfunction.
What is the QUICKI index?
The Quantitative Insulin Sensitivity Check Index (QUICKI = 1 / [log(Glucose) + log(Insulin)]) is an inverse logarithmic index of insulin sensitivity. Values above 0.38 reflect healthy insulin sensitivity; values under 0.33 indicate metabolic syndrome.